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| 카탈로그 번호 | ZA079013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Androctonus australis (Sahara scorpion) | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a | ||||
| 클론 ID | 4C1 | ||||
| 타겟 | Alpha-mammal toxin AaH2, AaHII, Neurotoxin 2, Neurotoxin II | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P01484 | ||||
| RRID | Anti-Sahara scorpion AaH II/Neurotoxin II Antibody (4C1) (abinScience Cat# ZA079013, RRID:AB_3728994) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Alpha-mammal toxin AaH2 (AaH II/Neurotoxin II) is a ~9 kDa protein. Alpha toxin that binds voltage-independently at site-3 of sodium channels (Nav), inhibits the inactivation of the activated channels, and weakly inhibits activation, thereby blocking neuronal transmission. Inserts into voltage-sensing domain IV to stabilize a deactivated state, thereby preventing fast-inactivation. Principally slows the inactivation process of TTX-sensitive sodium channels. It is active on mammalian brain Nav1.2/SCN2A (EC(50)human=0.72 nM, EC(50)rat=2.6 nM), on rat skeletal muscle Nav1.4/SCN4A (EC(50)=2.2 nM), and on human neuronal Nav1.7/SCN9A (EC(50)=6.8-51.7 nM). In vivo, intraplantar injection into mice induces spontaneous pain responses. 1. Clairfeuille, T. et al. (2019) Science (New York, N.Y.) 363. PMID: 30733386 2. Abbas, N. et al. (2013) Pain 154, 1204-15. PMID: 23685008 3. Alami, M. et al. (2003) The Biochemical journal 375, 551-60. PMID: 12911331 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Sahara scorpion AaH II/Neurotoxin II Antibody (4C1)
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