Anti-SCNN1A Polyclonal Antibody (HW302014)

Name: Anti-SCNN1A Polyclonal Antibody
Brand: abinScience
SKU: HW302014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HW302014

설명

Anti-SCNN1A Polyclonal Antibody (HW302014) is a rabbit polyclonal antibody detecting SCNN1A/SCNN1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human SCNN1A (Tyr112-Thr543).

타겟

ENaCA, SCNN1A, Epithelial Na(+) channel subunit alpha, SCNEA, SCNN1, Alpha-NaCH, Amiloride-sensitive sodium channel subunit alpha, Nonvoltage-gated sodium channel 1 subunit alpha, Alpha-ENaC

정제

Purified by antigen affinity column.

등록번호

P37088

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Epithelial sodium channel subunit alpha (SCNN1A/SCNN1) is a ~75 kDa protein. This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance.

1. Noreng, S. et al. (2018) eLife 7. PMID: 30251954

2. Noreng, S. et al. (2020) eLife 9. PMID: 32729833

3. McDonald, FJ. et al. (1994) The American journal of physiology 266, L728-34. PMID: 8023962

4. Voilley, N. et al. (1994) Proceedings of the National Academy of Sciences of the United States of America 91, 247-51. PMID: 8278374

5. Goulet, CC. et al. (1998) The Journal of biological chemistry 273, 30012-7. PMID: 9792722

6. Hobbs, CA. et al. (2013) American journal of physiology. Lung cellular and molecular physiology 305, L990-L1001. PMID: 24124190

7. Salih, M. et al. (2017) Journal of the American Society of Nephrology : JASN 28, 3291-3299. PMID: 28710092

8. Saxena, A. et al. (2002) The Journal of clinical endocrinology and metabolism 87, 3344-50. PMID: 12107247

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-SCNN1A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-SCNN1A Polyclonal Antibody (HW302014)

개요

이미지

참고 문헌

데이터시트

SDS