Anti-SEBOV Glycoprotein GP1 Polyclonal Antibody (VK623034)

Name: Anti-SEBOV Glycoprotein GP1 Polyclonal Antibody
Brand: abinScience
SKU: VK623034
Price: 168 USD
Availability: InStock

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사양:

50ug
100ug

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개요
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SDS

개요

카탈로그 번호

VK623034

설명

Anti-SEBOV GP1 Polyclonal Antibody (VK623034) is a rabbit polyclonal antibody detecting SEBOV GP1 in ELISA, IHC, WB. Suitable for Sudan ebolavirus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Sudan ebolavirus (SEBOV) (Sudan Ebola virus)

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant SEBOV GP1 (Met33-Leu495).

타겟

Envelope glycoprotein, GP, GP1,

내독소 수준

Please contact with the lab for this information.

순도

>90% as determined by SDS-PAGE.

정제

Purified by antigen affinity column.

등록번호

Q05320

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300.

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제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000,IHC:1:50-1:500,WB:1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Envelope glycoprotein (GP1) is a ~74 kDa protein. Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, down-regulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes.

참고사항

For research use only

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