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| 카탈로그 번호 | HB906014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-SERPINB1 Polyclonal Antibody (HB906014) is a rabbit polyclonal antibody detecting SERPINB1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human SERPINB1 (Leu13-Leu252). | ||||||||
| 타겟 | ELANH2, Peptidase inhibitor 2, Serpin B1, SERPINB1, MNEI, M/NEI, EI, LEI, PI2, Monocyte/neutrophil elastase inhibitor, PI-2, Leukocyte elastase inhibitor | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P30740 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Leukocyte elastase inhibitor (SERPINB1) is a ~42 kDa protein. Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also acts as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. 1. Choi, YJ. et al. (2019) Nature immunology 20, 276-287. PMID: 30692621 2. Cooley, J. et al. (2001) Biochemistry 40, 15762-70. PMID: 11747453 3. Wang, L. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 1319-30. PMID: 23269243 4. El Ouaamari, A. et al. (2016) Cell metabolism 23, 194-205. PMID: 26701651 | ||||||||
| 참고사항 | For research use only. |
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