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| 카탈로그 번호 | VK100014 | ||||
|---|---|---|---|---|---|
| 설명 |
Anti-SIV VPX Polyclonal Antibody (VK100014) is a rabbit polyclonal antibody detecting vpx protein in ELISA, IHC, WB.
Highlights
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| 종 반응성 | Simian immunodeficiency virus (SIV) | ||||
| 응용 분야 | ELISA, IHC, WB | ||||
| 숙주 종 | Rabbit | ||||
| 클론성 | Polyclonal | ||||
| 이소타입 | IgG | ||||
| 면역원 | E. coli - derived recombinant SIV VPX (Asp26-Cys90). | ||||
| 타겟 | vpx protein, vpx | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 정제 | Purified by antigen affinity column. | ||||
| 등록번호 | Q02842 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Protein Vpx is a ~14 kDa protein. Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host DCAF1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription. | ||||
| 참고사항 | For research use only. |
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