Anti-SKP2 Polyclonal Antibody (HC635014)

Name: Anti-SKP2 Polyclonal Antibody
Brand: abinScience
SKU: HC635014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD): --

사양:

50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HC635014

설명

Anti-SKP2 Polyclonal Antibody (HC635014) is a rabbit polyclonal antibody detecting SKP2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human SKP2 (Lys43-Leu354).

타겟

Cyclin-A/CDK2-associated protein p45, F-box/LRR-repeat protein 1, S-phase kinase-associated protein 2, SKP2, p45skp2, FBXL1, F-box protein Skp2

정제

Purified by antigen affinity column.

등록번호

Q13309

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

S-phase kinase-associated protein 2 (SKP2) is a ~47 kDa protein. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1.

1. Yu, ZK. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 11324-9. PMID: 9736735

2. Méndez, J. et al. (2002) Molecular cell 9, 481-91. PMID: 11931757

3. Tedesco, D. et al. (2002) Genes & development 16, 2946-57. PMID: 12435635

4. von der Lehr, N. et al. (2003) Molecular cell 11, 1189-200. PMID: 12769844

5. Li, X. et al. (2003) The Journal of biological chemistry 278, 30854-8. PMID: 12840033

6. Tokarz, S. et al. (2004) The Journal of biological chemistry 279, 46424-30. PMID: 15342634

7. Huang, H. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 1649-54. PMID: 15668399

8. Jiang, H. et al. (2005) Molecular cell 18, 699-709. PMID: 15949444

9. Barboric, M. et al. (2005) Journal of virology 79, 11135-41. PMID: 16103164

10. Wang, W. et al. (2005) Biochemistry 44, 14553-64. PMID: 16262255

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-SKP2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-SKP2 Polyclonal Antibody (HC635014)

개요

이미지

참고 문헌

데이터시트

SDS