Anti-SLC19A1 Polyclonal Antibody (HW317014)

Name: Anti-SLC19A1 Polyclonal Antibody
Brand: abinScience
SKU: HW317014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD): --

사양:

50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HW317014

설명

Anti-SLC19A1 Polyclonal Antibody (HW317014) is a rabbit polyclonal antibody detecting SLC19A1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human SLC19A1 (Leu455-Gln591).

타겟

Intestinal folate carrier 1, FOLT, Solute carrier family 19 member 1, RFC1, hSLC19A1, IFC-1, SLC19A1, RFT-1, FLOT1, RFC, Placental folate transporter, Reduced folate transporter 1, Reduced folate transporter, Reduced folate carrier protein, hRFC

정제

Purified by antigen affinity column.

등록번호

P41440

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Reduced folate transporter (SLC19A1) is a ~64 kDa protein. Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions. Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses. Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also mediates the import of antifolate drug methotrexate.

1. Chancy, CD. et al. (2000) The Journal of biological chemistry 275, 20676-84. PMID: 10787414

2. Witt, TL. et al. (2004) The Journal of biological chemistry 279, 46755-63. PMID: 15337749

3. Hou, Z. et al. (2005) The Journal of biological chemistry 280, 36206-13. PMID: 16115875

4. Visentin, M. et al. (2012) Molecular pharmacology 82, 209-16. PMID: 22554803

5. Ritchie, C. et al. (2019) Molecular cell 75, 372-381.e5. PMID: 31126740

6. Luteijn, RD. et al. (2019) Nature 573, 434-438. PMID: 31511694

7. Svaton, M. et al. (2020) Blood 135, 2427-2431. PMID: 32276275

8. Wright, NJ. et al. (2022) Nature 609, 1056-1062. PMID: 36071163

9. Zhang, Q. et al. (2022) Nature 612, 170-176. PMID: 36265513

10. Dang, Y. et al. (2022) Cell discovery 8, 141. PMID: 36575193

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-SLC19A1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-SLC19A1 Polyclonal Antibody (HW317014)

개요

이미지

참고 문헌

데이터시트

SDS