Anti-SMAD1 Polyclonal Antibody (HS725014)

Name: Anti-SMAD1 Polyclonal Antibody
Brand: abinScience
SKU: HS725014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD): --

사양:

50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HS725014

설명

Anti-SMAD1 Polyclonal Antibody (HS725014) is a rabbit polyclonal antibody detecting SMAD1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Coturnix japonica.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human SMAD1 (Asp259-Ser462).

타겟

BSP1, Mothers against DPP homolog 1, Mothers against decapentaplegic homolog 1, SMAD1, Transforming growth factor-beta-signaling protein 1, MADH1, JV4-1, MADR1, SMAD family member 1, hSMAD1, SMAD 1, MAD homolog 1, Mad-related protein 1, BSP-1, Smad1

정제

Purified by antigen affinity column.

등록번호

Q15797

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

SMAD family member 1 (SMAD1) is a ~52 kDa protein. Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis. Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import.

1. Kretzschmar, M. et al. (1997) Nature 389, 618-22. PMID: 9335504

2. Wu, J. et al. (2021) The Journal of biological chemistry 296, 100496. PMID: 33667543

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-SMAD1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-SMAD1 Polyclonal Antibody (HS725014)

개요

이미지

참고 문헌

데이터시트

SDS