中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HB389014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-SMYD5 Polyclonal Antibody (HB389014) is a rabbit polyclonal antibody detecting Histone-lysine N-trimethyltransferase SMYD5; 2.1.1.372; Protein NN8-4AG; Retinoic acid-induced protein 15; SET and MYND domain-containing protein 5; [histone H4]-lysine20 N-trimethyltransferase SMYD5; SMYD5; RAI15 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
|
||||||||
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human SMYD5 (Met1-Glu384). | ||||||||
| 타겟 | Histone-lysine N-trimethyltransferase SMYD5; 2.1.1.372; Protein NN8-4AG; Retinoic acid-induced protein 15; SET and MYND domain-containing protein 5; [histone H4]-lysine20 N-trimethyltransferase SMYD5; SMYD5; RAI15 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q6GMV2, Q3TYX3 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Protein-lysine N-trimethyltransferase SMYD5 is a ~47 kDa protein. Protein-lysine N-trimethyltransferase that specifically catalyzes trimethylation of 'Lys-22' of the RPL40/eL40 subunit of the 60S ribosome, thereby promoting translation elongation and protein synthesis. May also act as a histone methyltransferase in the context of histone octamers, but not on nucleosome substrates: trimethylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 to form H3K36me3 and H4K20me3, respectively. The histone methyltransferase activity, which is independent of its SET domain, is however unsure in vivo. In association with the NCoR corepressor complex, involved in the repression of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages, possibly by catalyzing the formation of H4K20me3 at the gene promoters. Plays an important role in embryonic stem (ES) cell self-renewal and differentiation. 1. Park, J. et al. (2024) Nature 632, 656-663. PMID: 39048817 2. Miao, B. et al. (2024) Cell research 34, 648-660. PMID: 39103523 3. Kidder, BL. et al. (2017) Cancer research 77, 6729-6745. PMID: 28951459 | ||||||||
| 참고사항 | For research use only |
문의하기
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
