Anti-STAT2 Polyclonal Antibody (HW807014)

Name: Anti-STAT2 Polyclonal Antibody
Brand: abinScience
SKU: HW807014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HW807014

설명

Anti-STAT2 Polyclonal Antibody (HW807014) is a rabbit polyclonal antibody detecting STAT2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human STAT2 (Glu616-Ser849).

타겟

p113, STAT2, Signal transducer and activator of transcription 2

정제

Purified by antigen affinity column.

등록번호

P52630

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Signal transducer and activator of transcription 2 (STAT2) is a ~97 kDa protein. Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs.

1. Hambleton, S. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 3053-8. PMID: 23391734

2. Bluyssen, HA. et al. (1997) The Journal of biological chemistry 272, 4600-5. PMID: 9020188

3. Arimoto, KI. et al. (2017) Nature structural & molecular biology 24, 279-289. PMID: 28165510

4. Shahni, R. et al. (2015) Brain : a journal of neurology 138, 2834-46. PMID: 26122121

참고사항

For research use only.

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참고 문헌

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Anti-STAT2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-STAT2 Polyclonal Antibody (HW807014)

개요

이미지

참고 문헌

데이터시트

SDS