Anti-SUV39H1 Polyclonal Antibody (HT471014)

Name: Anti-SUV39H1 Polyclonal Antibody
Brand: abinScience
SKU: HT471014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HT471014

설명

Anti-SUV39H1 Polyclonal Antibody (HT471014) is a rabbit polyclonal antibody detecting SUV39H1 in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human SUV39H1 (Gly7-Met271).

타겟

Position-effect variegation 3-9 homolog, SUV39H, H3-K9-HMTase 1, SUV39H1, Histone-lysine N-methyltransferase SUV39H1, Su(var)3-9 homolog 1, Lysine N-methyltransferase 1A, Histone H3-K9 methyltransferase 1, Suppressor of variegation 3-9 homolog 1, KMT1A

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

O43463

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Histone-lysine N-methyltransferase SUV39H1 is a ~47 kDa protein. Histone methyltransferase that specifically mediates trimethylation of 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' (H3K9me1) as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats.

1. Rea, S. et al. (2000) Nature 406, 593-9. PMID: 10949293

2. Lachner, M. et al. (2001) Nature 410, 116-20. PMID: 11242053

3. Vaquero, A. et al. (2007) Nature 450, 440-4. PMID: 18004385

4. Zhou, L. et al. (2025) Science (New York, N.Y.) 389, 309-316. PMID: 40440427

5. Nielsen, SJ. et al. (2001) Nature 412, 561-5. PMID: 11484059

6. Ait-Si-Ali, S. et al. (2004) The EMBO journal 23, 605-15. PMID: 14765126

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-SUV39H1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-SUV39H1 Polyclonal Antibody (HT471014)

개요

이미지

참고 문헌

데이터시트

SDS

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