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| 카탈로그 번호 | VK099014 | ||||
|---|---|---|---|---|---|
| 설명 |
Anti-SV40 VP1 Polyclonal Antibody (VK099014) is a rabbit polyclonal antibody detecting Major structural protein VP1 in ELISA, IHC, WB. Suitable for Simian virus 40.
Highlights
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| 종 반응성 | Simian virus 40 (SV40) | ||||
| 응용 분야 | ELISA, IHC, WB | ||||
| 숙주 종 | Rabbit | ||||
| 클론성 | Polyclonal | ||||
| 이소타입 | IgG | ||||
| 면역원 | E. coli - derived recombinant SV40 VP1 (Pro21-Gln362). | ||||
| 타겟 | Major capsid protein VP1, Major structural protein VP1 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Purified by antigen affinity column. | ||||
| 등록번호 | P03087 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Major capsid protein VP1 is a ~39 kDa protein. Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Binds to N-glycolylneuraminic analog of the ganglioside GM1 on the cell surface to provide virion attachment to target cell. Once attached, the virion is internalized by caveolin-mediated endocytosis and traffics to the endoplasmic reticulum. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating. 1. Neu, U. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 5219-24. PMID: 18353982 2. Schelhaas, M. et al. (2007) Cell 131, 516-29. PMID: 17981119 | ||||
| 참고사항 | For research use only |
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