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| 카탈로그 번호 | HS853014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-TERF2 Polyclonal Antibody (HS853014) is a rabbit polyclonal antibody detecting TERF2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human TERF2 (Arg144-Gln438). | ||||||||
| 타겟 | Telomeric repeat-binding factor 2, Telomeric DNA-binding protein, TERF2, TRBF2, TTAGGG repeat-binding factor 2, TRF2 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q15554 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Telomeric repeat-binding factor 2 (TERF2) is a ~59 kDa protein. Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. 1. Court, R. et al. (2005) EMBO reports 6, 39-45. PMID: 15608617 2. de Lange, T. (2005) Genes & development 19, 2100-10. PMID: 16166375 3. Ye, J. et al. (2010) Cell 142, 230-42. PMID: 20655466 4. Rai, R. et al. (2017) Molecular cell 65, 801-817.e4. PMID: 28216226 5. Li, P. et al. (2019) International journal of biological sciences 15, 2350-2362. PMID: 31595153 6. Broccoli, D. et al. (1997) Nature genetics 17, 231-5. PMID: 9326950 7. Bilaud, T. et al. (1997) Nature genetics 17, 236-9. PMID: 9326951 8. van Steensel, B. et al. (1998) Cell 92, 401-13. PMID: 9476899 | ||||||||
| 참고사항 | For research use only. |
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