Anti-TIMP3 Polyclonal Antibody (HW471014)

Name: Anti-TIMP3 Polyclonal Antibody
Brand: abinScience
SKU: HW471014
Price: 96 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HW471014

설명

Anti-TIMP3 Polyclonal Antibody (HW471014) is a rabbit polyclonal antibody detecting TIMP3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Equus caballus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human TIMP3 (Cys24-Pro211).

타겟

Protein MIG-5, TIMP-3, Tissue inhibitor of metalloproteinases 3, TIMP3, Metalloproteinase inhibitor 3

정제

Purified by antigen affinity column.

등록번호

P35625

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Metalloproteinase inhibitor 3 (TIMP3) is a ~24 kDa protein. Mediates a variety of processes including matrix regulation and turnover, inflammation, and angiogenesis, through reversible inhibition of zinc protease superfamily enzymes, primarily matrix metalloproteinases (MMPs). Regulates extracellular matrix (ECM) remodeling through inhibition of matrix metalloproteinases (MMP) including MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Additionally, modulates the processing of amyloid precursor protein (APP) and apolipoprotein E receptor ApoER2 by inhibiting two alpha-secretases ADAM10 and ADAM17. Functions as a tumor suppressor and a potent inhibitor of angiogenesis. Exerts its anti-angiogenic effect by directly interacting with vascular endothelial growth factor (VEGF) receptor-2/KDR, preventing its binding to the VEGFA ligand.

1. Hoe, HS. et al. (2007) The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 10895-905. PMID: 17913923

2. Qi, JH. et al. (2003) Nature medicine 9, 407-15. PMID: 12652295

3. Qi, JH. et al. (2015) Apoptosis : an international journal on programmed cell death 20, 523-34. PMID: 25558000

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-TIMP3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-TIMP3 Polyclonal Antibody (HW471014)

개요

이미지

참고 문헌

데이터시트

SDS

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