Anti-TNKS2 Polyclonal Antibody (HV525014)

Name: Anti-TNKS2 Polyclonal Antibody
Brand: abinScience
SKU: HV525014
Price: 168 USD
Availability: InStock

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HV525014

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human TNKS2 (Ser959-Gly1166).

타겟

TANK2, ADP-ribosyltransferase diphtheria toxin-like 6, Tankyrase-like protein, Poly [ADP-ribose] polymerase tankyrase-2, Tankyrase-related protein, TNKS2, Tankyrase II, ARTD6, Poly [ADP-ribose] polymerase 5B, Tankyrase-2, PARP5B, TNKL, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, TNKS-2, Protein poly-ADP-ribosyltransferase tankyrase-2

정제

Purified by antigen affinity column.

등록번호

Q9H2K2

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2) is a ~126 kDa protein. Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity.

1. Cook, BD. et al. (2002) Molecular and cellular biology 22, 332-42. PMID: 11739745

2. Sbodio, JI. et al. (2002) The Biochemical journal 361, 451-9. PMID: 11802774

3. Huang, SM. et al. (2009) Nature 461, 614-20. PMID: 19759537

4. Zhang, Y. et al. (2011) Nature cell biology 13, 623-9. PMID: 21478859

5. Cho-Park, PF. et al. (2013) Cell 153, 614-27. PMID: 23622245

6. Vyas, S. et al. (2014) Nature communications 5, 4426. PMID: 25043379

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-TNKS2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-TNKS2 Polyclonal Antibody (HV525014)

개요

이미지

참고 문헌

데이터시트

SDS

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