Anti-TPPP Polyclonal Antibody (HF892014)

Name: Anti-TPPP Polyclonal Antibody
Brand: abinScience
SKU: HF892014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HF892014

설명

Anti-TPPP Polyclonal Antibody (HF892014) is a rabbit polyclonal antibody detecting TPPP in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human TPPP (Ala8-Thr210).

타겟

25 kDa brain-specific protein, TPPP/p25, Tubulin polymerization-promoting protein, p24, p25-alpha, TPPP, TPPP1

정제

Purified by antigen affinity column.

등록번호

O94811

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Tubulin polymerization-promoting protein (TPPP) is a ~23 kDa protein. Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath. Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath. Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes. Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear. In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network.

1. Fu, MM. et al. (2019) Cell 179, 132-146.e14. PMID: 31522887

2. Doi, S. et al. (2021) Cell calcium 96, 102404. PMID: 33831707

3. Zotter, A. et al. (2011) FEBS letters 585, 803-8. PMID: 21316364

4. Zotter, Á. et al. (2011) Biochemistry 50, 9568-78. PMID: 21995432

5. Vincze, O. et al. (2006) Biochemistry 45, 13818-26. PMID: 17105200

6. Hlavanda, E. et al. (2007) The Journal of biological chemistry 282, 29531-9. PMID: 17693641

7. Acevedo, K. et al. (2007) Experimental cell research 313, 4091-106. PMID: 18028908

8. DeBonis, S. et al. (2015) Scientific reports 5, 13242. PMID: 26289831

9. Tokési, N. et al. (2010) The Journal of biological chemistry 285, 17896-906. PMID: 20308065

참고사항

For research use only.

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참고 문헌

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Anti-TPPP Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-TPPP Polyclonal Antibody (HF892014)

개요

이미지

참고 문헌

데이터시트

SDS