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| 카탈로그 번호 | HS785014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-TRADD Polyclonal Antibody (HS785014) is a rabbit polyclonal antibody detecting TRADD in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human TRADD (Met61-Leu297). | ||||||||
| 타겟 | TRADD, TNFR1-associated DEATH domain protein, Tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFRSF1A-associated via death domain | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q15628 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) is a ~34 kDa protein. Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. 1. Li, S. et al. (2013) Nature 501, 242-6. PMID: 23955153 2. Hsu, H. et al. (1995) Cell 81, 495-504. PMID: 7758105 3. Hsu, H. et al. (1996) Immunity 4, 387-96. PMID: 8612133 | ||||||||
| 참고사항 | For research use only. |
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