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| 카탈로그 번호 | HF525014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human TRPA1 (Asp63-Ile370). | ||||||||
| 타겟 | Transformation-sensitive protein p120, TRPA1, Transient receptor potential cation channel subfamily A member 1, Ankyrin-like with transmembrane domains protein 1, ANKTM1, Wasabi receptor | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O75762 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Transient receptor potential cation channel subfamily A member 1 (TRPA1) is a ~127 kDa protein. Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function. Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization. Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner. 1. Zurborg, S. et al. (2007) Nature neuroscience 10, 277-9. PMID: 17259981 2. Bobkov, YV. et al. (2011) Biochimica et biophysica acta 1808, 1120-8. PMID: 21195050 3. Takahashi, N. et al. (2011) Nature chemical biology 7, 701-11. PMID: 21873995 4. Buday, T. et al. (2012) Cough (London, England) 8, 11. PMID: 23199233 5. Moparthi, L. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 16901-6. PMID: 25389312 6. Liu, C. et al. (2021) Neuron 109, 273-284.e4. PMID: 33152265 7. Hu, H. et al. (2009) Nature chemical biology 5, 183-90. PMID: 19202543 8. Kremeyer, B. et al. (2010) Neuron 66, 671-80. PMID: 20547126 | ||||||||
| 참고사항 | For research use only. |
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