Anti-TTK Polyclonal Antibody (HW490014)

Name: Anti-TTK Polyclonal Antibody
Brand: abinScience
SKU: HW490014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HW490014

설명

Anti-TTK Polyclonal Antibody (HW490014) is a rabbit polyclonal antibody detecting TTK in ELISA, IHC, WB. Suitable for Human, Macaca fascicularis, and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human TTK (Gly532-Ala787).

타겟

Dual specificity protein kinase TTK, MPS1L1, Phosphotyrosine picked threonine-protein kinase, TTK, PYT, MPS1

정제

Purified by antigen affinity column.

등록번호

P33981

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Dual specificity protein kinase TTK is a ~97 kDa protein. Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments. Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint. Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore. Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments. Phosphorylates KNL1, KNTC1 and autophosphorylates.

1. Jelluma, N. et al. (2008) Cell 132, 233-46. PMID: 18243099

2. Maciejowski, J. et al. (2017) Developmental cell 41, 143-156.e6. PMID: 28441529

3. Ji, W. et al. (2018) The Journal of biological chemistry 293, 484-496. PMID: 29162720

4. Yang, H. et al. (2019) Molecular biology of the cell 30, 1060-1068. PMID: 30785839

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-TTK Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-TTK Polyclonal Antibody (HW490014)

개요

이미지

참고 문헌

데이터시트

SDS