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| 카탈로그 번호 | HX198014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human UBE2L3 (Ser4-Asp154). | ||||||||
| 타겟 | UBE2L3, Ubiquitin-conjugating enzyme E2-F1, UBCH7, Ubiquitin-conjugating enzyme E2 L3, UBCE7, L-UBC, E2 ubiquitin-conjugating enzyme L3, UbcH7, Ubiquitin-protein ligase L3, Ubiquitin carrier protein L3 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P68036 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) is a ~17 kDa protein. Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine; in contrast, it has activity with the RBR family E3 enzymes, such as PRKN, RNF31 and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates ubiquitination by the CUL9-RBX1 complex. In vitro catalyzes 'Lys-11'-linked polyubiquitination. 1. Horn-Ghetko, D. et al. (2024) Nature structural & molecular biology 31, 1083-1094. PMID: 38605244 | ||||||||
| 참고사항 | For research use only. |
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