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| 카탈로그 번호 | HB024014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-UCP1 Polyclonal Antibody (HB024014) is a rabbit polyclonal antibody detecting UCP1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human UCP1 (Met1-Thr307). | ||||||||
| 타겟 | Solute carrier family 25 member 7, UCP1, SLC25A7, Mitochondrial brown fat uncoupling protein 1, Thermogenin, UCP, UCP 1 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P25874 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Mitochondrial brown fat uncoupling protein 1 (UCP1) is a ~33 kDa protein. Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria. 1. Hoang, T. et al. (2013) The Journal of biological chemistry 288, 36244-58. PMID: 24196960 2. Zhao, L. et al. (2017) Structure (London, England : 1993) 25, 1371-1379.e3. PMID: 28781081 | ||||||||
| 참고사항 | For research use only. |
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