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| 카탈로그 번호 | HB585014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-USP12 Polyclonal Antibody (HB585014) is a rabbit polyclonal antibody detecting Ubiquitin carboxyl-terminal hydrolase 12; 3.4.19.12; Deubiquitinating enzyme 12; Ubiquitin thioesterase 12; Ubiquitin-hydrolyzing enzyme 1; Ubiquitin-specific-processing protease 12; USP12; UBH1; USP12L1 in ELISA, IHC, WB. Suitable for Human, Frog, Bovine, Mouse, and Zebrafish.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human USP12 (Ala20-Asp370). | ||||||||
| 타겟 | Ubiquitin carboxyl-terminal hydrolase 12; 3.4.19.12; Deubiquitinating enzyme 12; Ubiquitin thioesterase 12; Ubiquitin-hydrolyzing enzyme 1; Ubiquitin-specific-processing protease 12; USP12; UBH1; USP12L1 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O75317, Q52KZ6, Q5M981, A5D9H7, Q9D9M2, A4FUN7, F1M625, P62068, A5WWB0, P62069 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Ubiquitin carboxyl-terminal hydrolase 12 (USP12) is a ~42 kDa protein. Deubiquitinating enzyme that plays various roles in the regulation of the immune response and inflammation. During TCR engagement and activation, translocates into the cytoplasm and deubiquitinates its substrates LAT and TRAT1 and prevents their lysosome-dependent degradation to stabilize the TCR signaling complex at the plasma membrane. Plays an essential role in the selective LPS-induced macrophage response through the activation of NF-kappa-B pathway. In addition, promotes that antiviral immune response through targeting DNA sensor IFI16 to inhibit its proteasome-dependent degradation. Participates in the interferon signaling pathway and antiviral response independently of its deubiquitinase activity by maintaining nuclear phosphorylated STAT1 levels via inhibition of its CREBBP-mediated acetylation and subsequent dephosphorylation. 1. Cohn, MA. et al. (2009) The Journal of biological chemistry 284, 5343-51. PMID: 19075014 2. Li, H. et al. (2016) Molecular cell 63, 249-260. PMID: 27373336 3. Jahan, AS. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, E705-14. PMID: 26811477 4. Nayak, TKS. et al. (2017) Biochemical and biophysical research communications 483, 69-74. PMID: 28063927 5. Fu, Y. et al. (2023) PLoS pathogens 19, e1011480. PMID: 37410794 6. Liu, J. et al. (2020) PLoS pathogens 16, e1008215. PMID: 31899788 7. Choi, HS. et al. (2022) International journal of molecular sciences 23. PMID: 36361894 8. Moretti, J. et al. (2012) The Journal of biological chemistry 287, 29429-41. PMID: 22778262 9. Aron, R. et al. (2018) Nature communications 9, 3191. PMID: 30266909 10. Gangula, NR. et al. (2013) The Journal of biological chemistry 288, 34545-54. PMID: 24145035 | ||||||||
| 참고사항 | For research use only |
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