Anti-ZC3H12A Polyclonal Antibody (HS805014)

Name: Anti-ZC3H12A Polyclonal Antibody
Brand: abinScience
SKU: HS805014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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개요

카탈로그 번호

HS805014

설명

Anti-ZC3H12A Polyclonal Antibody (HS805014) is a rabbit polyclonal antibody detecting ZC3H12A in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human ZC3H12A (Asp426-Glu599).

타겟

Regnase-1, MCPIP, Endoribonuclease ZC3H12A, Reg1, MCPIP-1, MCP-induced protein 1, ZC3H12A, Zinc finger CCCH domain-containing protein 12A, MCPIP1, Monocyte chemotactic protein-induced protein 1

정제

Purified by antigen affinity column.

등록번호

Q5D1E8

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Endoribonuclease ZC3H12A is a ~65 kDa protein. Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay. Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation. Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs.

1. Mizgalska, D. et al. (2009) The FEBS journal 276, 7386-99. PMID: 19909337

2. Garg, AV. et al. (2015) Immunity 43, 475-87. PMID: 26320658

3. Xu, J. et al. (2012) Nucleic acids research 40, 6957-65. PMID: 22561375

4. Huang, S. et al. (2015) The Journal of biological chemistry 290, 20782-20792. PMID: 26134560

5. Suzuki, HI. et al. (2011) Molecular cell 44, 424-36. PMID: 22055188

6. Roy, A. et al. (2013) American journal of physiology. Cell physiology 305, C1021-32. PMID: 24048733

7. Wang, W. et al. (2015) The Journal of biological chemistry 290, 13372-85. PMID: 25861989

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-ZC3H12A Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-ZC3H12A Polyclonal Antibody (HS805014)

개요

이미지

참고 문헌

데이터시트

SDS