Anti-ZDHHC5 Polyclonal Antibody (HA293014)

Name: Anti-ZDHHC5 Polyclonal Antibody
Brand: abinScience
SKU: HA293014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HA293014

설명

Anti-ZDHHC5 Polyclonal Antibody (HA293014) is a rabbit polyclonal antibody detecting ZDHHC5 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human ZDHHC5 (Ser63-Tyr148).

타겟

ZDHHC5, Palmitoyltransferase ZDHHC5, DHHC-5, Zinc finger DHHC domain-containing protein 5, ZNF375, KIAA1748, Zinc finger protein 375

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q9C0B5

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Palmitoyltransferase ZDHHC5 is a ~77 kDa protein. Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions. Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins. Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2. Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2.

1. Kokkola, T. et al. (2011) FEBS letters 585, 2665-70. PMID: 21820437

2. Badawy, SMM. et al. (2017) Scientific reports 7, 16552. PMID: 29185452

3. Woodley, KT. et al. (2019) EMBO reports 20, e47472. PMID: 31402609

4. Lu, Y. et al. (2019) Science (New York, N.Y.) 366, 460-467. PMID: 31649195

5. Dixon, CL. et al. (2021) Journal of lipid research 62, 100097. PMID: 34293401

6. Zheng, S. et al. (2023) Molecular cell 83, 4570-4585.e7. PMID: 38092000

7. Balasubramanian, A. et al. (2024) Science immunology 9, eadn1452. PMID: 38530158

8. Du, G. et al. (2024) Nature 630, 437-446. PMID: 38599239

9. Brigidi, GS. et al. (2015) Nature communications 6, 8200. PMID: 26334723

10. Hao, JW. et al. (2020) Nature communications 11, 4765. PMID: 32958780

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-ZDHHC5 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-ZDHHC5 Polyclonal Antibody (HA293014)

개요

이미지

참고 문헌

데이터시트

SDS