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| 카탈로그 번호 | VK518023 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Zaire ebolavirus (ZEBOV) (Zaire Ebola virus) | ||||
| 응용 분야 | ELISA, IF | ||||
| 숙주 종 | Human | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG | ||||
| 클론 ID | KZ51 | ||||
| 타겟 | NP, Nucleoprotein, Nucleocapsid protein | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P18272 | ||||
| RRID | Anti-ZEBOV NP/Nucleoprotein Antibody (KZ51) (abinScience Cat# VK518023, RRID:AB_3727247) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Nucleoprotein (NP) is a ~83 kDa protein. Oligomerizes into helical capsid to encapsidate the viral genome, protecting it from nucleases and the cellular innate immune response. VP35 binds to and stabilizes monomeric NP, keeping it soluble. Upon virus replication, NP is recruited to bind cooperatively viral genomic RNA and VP35 is released. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. The nucleocapsid is helical with a pitch of 10.81 NP per turn and a diameter of about 22nm. 1. Johnson, RF. et al. (2006) Virology journal 3, 31. PMID: 16719918 2. Leung, DW. et al. (2015) Cell reports 11, 376-89. PMID: 25865894 3. Kirchdoerfer, RN. et al. (2015) Cell reports 12, 140-149. PMID: 26119732 4. Sugita, Y. et al. (2018) Nature 563, 137-140. PMID: 30333622 5. Wan, W. et al. (2017) Nature 551, 394-397. PMID: 29144446 6. Beniac, DR. et al. (2012) PloS one 7, e29608. PMID: 22247782 7. Kirchdoerfer, RN. et al. (2016) PLoS pathogens 12, e1005937. PMID: 27755595 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-ZEBOV NP/Nucleoprotein Antibody (KZ51)
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