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| 카탈로그 번호 | VK425010 |
|---|---|
| 설명 |
InVivoMAb Anti-Chikungunya Virus/CHIKV VLP Antibody (m242) [m242] (VK425010) is a human monoclonal antibody detecting Structural polyprotein in ELISA, Neutralization. Suitable for Chikungunya virus.
|
| 종 반응성 | Chikungunya virus (CHIKV) |
| 응용 분야 | ELISA, Neutralization |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG1 |
| 클론 ID | m242 |
| 타겟 | Structural polyprotein, p130, Capsid protein, 3.4.21.90, Coat protein, C, Precursor of protein E3/E2, p62, pE2, Assembly protein E3, Spike glycoprotein E2, E2 envelope glycoprotein, 6K protein, Spike glycoprotein E1, E1 envelope glycoprotein |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 관련 제품 | pH 7.4 Dilution Buffer |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | Q8JUX5, Q1H8W5, Q5XXP3 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 배경 | Structural polyprotein (VLP) is a ~138 kDa protein. Forms an icosahedral capsid with a T=4 symmetry composed of 240 copies of the capsid protein surrounded by a lipid membrane through which penetrate 80 spikes composed of trimers of E1-E2 heterodimers. The capsid protein binds to the viral RNA genome at a site adjacent to a ribosome binding site for viral genome translation following genome release. Possesses a protease activity that results in its autocatalytic cleavage from the nascent structural protein. Following its self-cleavage, the capsid protein transiently associates with ribosomes, and within several minutes the protein binds to viral RNA and rapidly assembles into icosahedric core particles. The resulting nucleocapsid eventually associates with the cytoplasmic domain of the spike glycoprotein E2 at the cell membrane, leading to budding and formation of mature virions. 1. Webb, LG. et al. (2020) PLoS pathogens 16, e1008999. PMID: 33057424 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for InVivoMAb Anti-Chikungunya Virus/CHIKV VLP Antibody (m242)
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