InVivoMAb Anti-Clostridioides difficile Toxin A/tcdA Antibody (PA50) (JN085010)

Name: InVivoMAb Anti-Clostridioides difficile Toxin A/tcdA Antibody (PA50)
Brand: abinScience
SKU: JN085010
Price: 370 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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100ug
1mg

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호	JN085010
설명	InVivoMAb Anti-Clostridioides difficile Toxin A/tcdA Antibody (PA50) [PA50] (JN085010) is a human monoclonal antibody detecting toxA in Neutralization, SPR.
종 반응성	Clostridioides difficile
응용 분야	Neutralization, SPR
숙주 종	Human
클론성	Monoclonal
이소타입	IgG1, kappa
클론 ID	PA50
타겟	toxA, TcdA, Toxin A, Clostridioides difficile (Peptoclostridium difficile), Clostridium difficile Toxin
내독소 수준	Please contact with the lab for this information.
순도	>95% as determined by SDS-PAGE.
관련 제품	pH 7.4 Dilution Buffer
정제	Protein A/G purified from cell culture supernatant.
등록번호	P16154
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	Toxin A (tcdA) is a ~308 kDa protein. Precursor of a cytotoxin that targets and disrupts the colonic epithelium, inducing the host inflammatory and innate immune responses and resulting in diarrhea and pseudomembranous colitis. TcdA and TcdB constitute the main toxins that mediate the pathology of C.difficile infection, an opportunistic pathogen that colonizes the colon when the normal gut microbiome is disrupted. Compared to TcdB, TcdA is less virulent and less important for inducing the host inflammatory and innate immune responses. This form constitutes the precursor of the toxin: it enters into host cells and mediates autoprocessing to release the active toxin (Glucosyltransferase TcdA) into the host cytosol. Targets colonic epithelia by binding to some receptor, and enters host cells via clathrin-mediated endocytosis. 1. Kuehne, SA. et al. (2010) Nature 467, 711-3. PMID: 20844489 2. Lyras, D. et al. (2009) Nature 458, 1176-9. PMID: 19252482 3. Greco, A. et al. (2006) Nature structural & molecular biology 13, 460-1. PMID: 16622409 4. Tucker, KD. et al. (1991) Infection and immunity 59, 73-8. PMID: 1670930 5. Tao, L. et al. (2019) Nature microbiology 4, 1760-1769. PMID: 31160825 6. Tao, L. et al. (2016) Nature 538, 350-355. PMID: 27680706 7. Reineke, J. et al. (2007) Nature 446, 415-9. PMID: 17334356 8. Pruitt, RN. et al. (2009) The Journal of biological chemistry 284, 21934-21940. PMID: 19553670
참고사항	For research use only. Not suitable for clinical or therapeutic use.