中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | CF879010 |
|---|---|
| 설명 |
InVivoMAb Anti-Dog TNFa/TNF-alpha Antibody (Iv0271) [Iv0271] (CF879010) is a dog monoclonal antibody detecting TNF in Blocking, ELISA, FCM. Suitable for Dog.
Highlights
|
| 종 반응성 | Canine |
| 응용 분야 | Blocking, ELISA, FCM |
| 숙주 종 | Canine |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, kappa |
| 클론 ID | Iv0271 |
| 타겟 | C-domain 1, C-domain 2, Cachectin, ICD1, ICD2, Intracellular domain 1, Intracellular domain 2, N-terminal fragment, NTF, TNF, TNF-a, TNF-alpha, TNFA, TNFSF2, Tumor necrosis factor, Tumor necrosis factor ligand superfamily member 2, Tumor necrosis factor, membrane form, Tumor necrosis factor, soluble form |
| 내독소 수준 | < 1 EU/mg |
| 순도 | >95% as determined by SDS-PAGE. |
| 관련 제품 | pH 7.4 Dilution Buffer |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P51742 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 배경 | Tumor necrosis factor (TNFa/TNF-alpha) is a ~25 kDa protein. Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. TNFa is the therapeutic target of adalimumab (Humira). |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for InVivoMAb Anti-Dog TNFa/TNF-alpha Antibody (Iv0271)
Detects recombinant dog TNFa/TNF-alpha (Catalog No: CF879011) in indirect ELISA
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
