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| 카탈로그 번호 | HF964010 |
|---|---|
| 설명 |
InVivoMAb Anti-Human LRP6 Antibody (YW210.09) [YW210.09] (HF964010) is a mouse monoclonal antibody detecting LRP6 in ELISA, Neutralization, SPR. Suitable for Human.
Highlights
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Neutralization, SPR |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG2a, kappa |
| 클론 ID | YW210.09 |
| 타겟 | LRP6, LRP-6, Low-density lipoprotein receptor-related protein 6 |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 관련 제품 | pH 7.4 Dilution Buffer |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | O75581 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 배경 | Low-density lipoprotein receptor-related protein 6 (LRP6) is a ~180 kDa protein. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in various processes including retinal angiogenesis and bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation. 1. Mao, B. et al. (2001) Nature 411, 321-5. PMID: 11357136 2. Semënov, MV. et al. (2001) Current biology : CB 11, 951-61. PMID: 11448771 3. Li, X. et al. (2005) The Journal of biological chemistry 280, 19883-7. PMID: 15778503 4. Zeng, X. et al. (2005) Nature 438, 873-7. PMID: 16341017 5. Swiatek, W. et al. (2006) The Journal of biological chemistry 281, 12233-41. PMID: 16513652 6. Mi, K. et al. (2007) Journal of neurochemistry 101, 517-29. PMID: 17326769 7. Wei, Q. et al. (2007) The Journal of biological chemistry 282, 15903-11. PMID: 17400545 8. Piao, S. et al. (2008) PloS one 3, e4046. PMID: 19107203 9. Wu, G. et al. (2009) PloS one 4, e4926. PMID: 19293931 10. Chen, M. et al. (2009) The Journal of biological chemistry 284, 35040-8. PMID: 19801552 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for InVivoMAb Anti-Human LRP6 Antibody (YW210.09)
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