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| 카탈로그 번호 | MS856020 | ||||
|---|---|---|---|---|---|
| 설명 |
InVivoMAb Anti-Mouse IL17A Antibody (17F3) [17F3] (MS856020) is a mouse monoclonal antibody detecting CTLA-8 in ELISA, Neutralization. Suitable for Mouse.
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| 종 반응성 | Mouse | ||||
| 응용 분야 | ELISA, Neutralization | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG1, kappa | ||||
| 클론 ID | 17F3 | ||||
| 타겟 | CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL-17A, IL17, IL17A, Interleukin-17A | ||||
| 내독소 수준 | < 1 EU/mg | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 관련 제품 | pH 7.4 Dilution Buffer | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q62386 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Interleukin-17A (IL17A) is a ~17 kDa protein. Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. IL17A is the therapeutic target of secukinumab (Cosentyx). 1. Liang, SC. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 7791-9. PMID: 18025225 2. Ishigame, H. et al. (2009) Immunity 30, 108-19. PMID: 19144317 3. Lee, JS. et al. (2015) Immunity 43, 727-38. PMID: 26431948 4. Park, H. et al. (2005) Nature immunology 6, 1133-41. PMID: 16200068 5. Kuestner, RE. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 5462-73. PMID: 17911633 6. Chen, K. et al. (2016) Cell host & microbe 20, 596-605. PMID: 27923703 | ||||
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for InVivoMAb Anti-Mouse IL17A Antibody (17F3)
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