InVivoMAb Anti-SARS-CoV-2 S2/Spike protein S2' Antibody (D31) (VK749070)

Name: InVivoMAb Anti-SARS-CoV-2 S2/Spike protein S2' Antibody (D31)
Brand: abinScience
SKU: VK749070
Price: 370 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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사양:

100ug
1mg

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호	VK749070
설명	InVivoMAb Anti-SARS-CoV-2 S2/Spike protein S2' Antibody (D31) [D31] (VK749070) is a mouse monoclonal antibody detecting Spike glycoprotein in Blocking, ELISA.
종 반응성	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
응용 분야	Blocking, ELISA
숙주 종	Mouse
클론성	Monoclonal
이소타입	IgG2a, kappa
클론 ID	D31
타겟	Spike glycoprotein, S glycoprotein, Spike protein S2', S, 2, SARS-CoV-2 (2019-nCoV)
내독소 수준	Please contact with the lab for this information.
순도	>95% as determined by SDS-PAGE.
관련 제품	pH 7.4 Dilution Buffer
정제	Protein A/G purified from cell culture supernatant.
등록번호	P0DTC2
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	Spike glycoprotein (S2/Spike protein S2') is a ~141 kDa protein. Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. The major receptor is host ACE2. When S2/S2' has been cleaved, binding to the receptor triggers direct fusion at the cell membrane. When S2/S2' has not been cleaved, binding to the receptor results in internalization of the virus by endocytosis using host TFRC and GRM2 and leading to fusion of the virion membrane with the host endosomal membrane. Alternatively, may use NRP1/NRP2 and integrin as entry receptors. 1. Hoffmann, M. et al. (2020) Cell 181, 271-280.e8. PMID: 32142651 2. Walls, AC. et al. (2020) Cell 181, 281-292.e6. PMID: 32155444 3. Cao, W. et al. (2021) Biophysical journal 120, 1011-1019. PMID: 33607086 4. Takeda, M. (2022) Microbiology and immunology 66, 15-23. PMID: 34561887 5. Wrapp, D. et al. (2020) Science (New York, N.Y.) 367, 1260-1263. PMID: 32075877 6. Ou, X. et al. (2020) Nature communications 11, 1620. PMID: 32221306 7. Wang, J. et al. (2021) Cell discovery 7, 119. PMID: 34903715 8. Wang, X. et al. (2023) Journal of virology 97, e0161122. PMID: 36779763 9. Daly, JL. et al. (2020) Science (New York, N.Y.) 370, 861-865. PMID: 33082294 10. Cantuti-Castelvetri, L. et al. (2020) Science (New York, N.Y.) 370, 856-860. PMID: 33082293
참고사항	For research use only. Not suitable for clinical or therapeutic use.