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| 카탈로그 번호 | HW501012 |
|---|---|
| 설명 |
Recombinant Human ABCC1 Protein, N-His (HW501012) expressed in E. coli, spanning Glu848-Met967. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P33527 |
| 단백질 길이 | Glu848-Met967 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 15.61 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | ABCC1, ATP-binding cassette sub-family C member 1, EC:7.6.2.2, EC:7.6.2.3, Glutathione-S-conjugate-translocating ATPase ABCC1, LTC4 transporter, Leukotriene C(4) transporter, MRP, MRP1, Multidrug resistance-associated protein 1 |
| 배경 | Multidrug resistance-associated protein 1 is a ~171 kDa protein. Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. 1. Sjölinder, M. et al. (1999) Journal of lipid research 40, 439-46. PMID: 10064732 2. Robbiani, DF. et al. (2000) Cell 103, 757-68. PMID: 11114332 3. Conseil, G. et al. (2006) The Journal of biological chemistry 281, 43-50. PMID: 16230346 4. Leier, I. et al. (1994) The Journal of biological chemistry 269, 27807-10. PMID: 7961706 5. Stride, BD. et al. (1997) Molecular pharmacology 52, 344-53. PMID: 9281595 |
| 참고사항 | For research use only |
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