Human ACKR3 Recombinant Protein (N-GST & C-His) (HB259032)

Name: Human ACKR3 Recombinant Protein (N-GST & C-His)
Brand: abinScience
SKU: HB259032
Price: 211 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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사양:

50ug
100ug
1mg

수량:

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HB259032
설명	Recombinant Human ACKR3 Protein, N-GST & C-His (HB259032) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
발현 시스템	E. coli
등록번호	P25106
단백질 길이	Asp2-Ser41
응용 분야	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
종	Homo sapiens (Human)
성질	Recombinant
내독소 수준	Please contact with the lab for this information.
순도	>90% as determined by SDS-PAGE.
형태	Lyophilized
저장 완충액	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
재구성	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
배송	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	ACKR3, Atypical chemokine receptor 3, C-X-C chemokine receptor type 7, CMKOR1, CXC-R7, CXCR-7, CXCR7, Chemokine orphan receptor 1, G-protein coupled receptor 159, G-protein coupled receptor RDC1 homolog, GPR159, RDC-1, RDC1
배경	Atypical chemokine receptor 3 is a ~41 kDa protein. Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. 1. Balabanian, K. et al. (2005) The Journal of biological chemistry 280, 35760-6. PMID: 16107333 2. Kalatskaya, I. et al. (2009) Molecular pharmacology 75, 1240-7. PMID: 19255243 3. Levoye, A. et al. (2009) Blood 113, 6085-93. PMID: 19380869 4. Naumann, U. et al. (2010) PloS one 5, e9175. PMID: 20161793 5. Ray, P. et al. (2012) The international journal of biochemistry & cell biology 44, 669-78. PMID: 22300987 6. Burns, JM. et al. (2006) The Journal of experimental medicine 203, 2201-13. PMID: 16940167 7. Hartmann, TN. et al. (2008) Journal of leukocyte biology 84, 1130-40. PMID: 18653785 8. Rajagopal, S. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 628-32. PMID: 20018651
참고사항	For research use only