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| 카탈로그 번호 | HD298012 |
|---|---|
| 설명 |
Recombinant Human ADGRF1 Protein, N-His (HD298012) expressed in E. coli, spanning Thr298-Pro575. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q5T601 |
| 단백질 길이 | Thr298-Pro575 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 32.95 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | ADGRF1, ADGRF1 C-terminal fragment, ADGRF1 N-terminal fragment, Adhesion G-protein coupled receptor F1, Adhesion G-protein coupled receptor F1, C-terminal fragment, Adhesion G-protein coupled receptor F1, N-terminal fragment, G protein-coupled receptor 110, G protein-coupled receptor KPG_012, GPR110, PGR19 |
| 배경 | Adhesion G-protein coupled receptor F1 is a ~101 kDa protein. Adhesion G-protein coupled receptor (aGPCR) for N-docosahexaenoylethanolamine (synaptamide), an omega-3 fatty acid lipid highly enriched in the brain. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRF1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Also able to couple to G(q), G(i) and G(12)/G(13) G proteins; additional evidence is however required to confirm this result in vivo. Involved in the development of neurons and cognitive function. 1. Lee, JW. et al. (2016) Nature communications 7, 13123. PMID: 27759003 2. Huang, BX. et al. (2020) Communications biology 3, 109. PMID: 32144388 3. Qu, X. et al. (2022) Nature 604, 779-785. PMID: 35418679 4. Zhu, X. et al. (2022) Nature communications 13, 5513. PMID: 36127364 5. Jones, DTD. et al. (2023) Nature communications 14, 2490. PMID: 37120430 |
| 참고사항 | For research use only |
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