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| 카탈로그 번호 | HC753012 |
|---|---|
| 설명 |
Recombinant Human ADRA1B Protein, N-His-SUMO (HC753012) expressed in E. coli, spanning Arg225-Thr295. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P35368 |
| 단백질 길이 | Arg225-Thr295 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 20.42 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | ADRA1B, Alpha-1B adrenergic receptor, Alpha-1B adrenoceptor, Alpha-1B adrenoreceptor |
| 배경 | Alpha-1B adrenergic receptor is a ~56 kDa protein. Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1B binds the catecholamine ligands norepinephrine and epinephrine. Can also couple to G(14) and G(16) proteins. Nuclear ADRA1B forms heterooligomers with ADRA1A to regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. 1. Schwinn, DA. et al. (1995) The Journal of pharmacology and experimental therapeutics 272, 134-42. PMID: 7815325 2. Forray, C. et al. (1994) Molecular pharmacology 45, 703-8. PMID: 8183249 3. Wright, CD. et al. (2008) Circulation research 103, 992-1000. PMID: 18802028 4. Wright, CD. et al. (2012) Cellular signalling 24, 794-802. PMID: 22120526 5. Ogata, T. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 3811-6. PMID: 24567387 |
| 참고사항 | For research use only |
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