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| 카탈로그 번호 | HD029012 |
|---|---|
| 설명 |
Recombinant Human ASIP Protein, N-His-KSI (HD029012) expressed in E. coli, spanning His23-Cys132. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P42127 |
| 단백질 길이 | His23-Cys132 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 27.81 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | AGTI, AGTIL, ASIP, ASP, Agouti switch protein, Agouti-signaling protein |
| 배경 | Agouti-signaling protein is a ~14 kDa protein. Signaling protein that functions as an antagonist of melanocyte-stimulating-hormone receptor MC1R, thereby playing a role in the regulation of melanogenesis. Binding to MC1R prevents alpha-MSH-induced signaling and inhibits cAMP production, resulting in down-regulation of eumelanogenesis (brown/black pigment) and increased pheomelanin (yellow/red pigment) synthesis. In higher primates, Agouti may affect the quality of hair pigmentation rather than the pattern of pigment deposition. May also play a role in neuroendocrine aspects of melanocortin action. 1. Kempf, E. et al. (2022) Nature metabolism 4, 1697-1712. PMID: 36536132 2. Kanetsky, PA. et al. (2002) American journal of human genetics 70, 770-5. PMID: 11833005 |
| 참고사항 | For research use only |
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