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| 카탈로그 번호 | HP002022 |
|---|---|
| 설명 |
Recombinant Human ATP6V0A1 Protein, N-His (HP002022) expressed in E. coli, spanning Met1-Asn390. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q93050 |
| 단백질 길이 | Met1-Asn390 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 47.53 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | ATP6N1, ATP6N1A, ATP6V0A1, Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit, V-ATPase 116 kDa subunit a 1, V-type proton ATPase 116 kDa subunit a 1, VPP1, Vacuolar adenosine triphosphatase subunit Ac116, Vacuolar proton pump subunit 1, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 |
| 배경 | V-type proton ATPase 116 kDa subunit a 1 is a ~96 kDa protein. Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that transports protons across cellular membranes. V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles. In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment. Required for assembly and activity of the vacuolar ATPase. Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons. 1. Wang, L. et al. (2020) Molecular cell 80, 501-511.e3. PMID: 33065002 2. Aoto, K. et al. (2021) Nature communications 12, 2107. PMID: 33833240 3. Bott, LC. et al. (2021) Brain communications 3, fcab245. PMID: 34909687 |
| 참고사항 | For research use only |
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