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| 카탈로그 번호 | HD803012 |
|---|---|
| 설명 |
Recombinant Human B4GALT4 Protein, N-His (HD803012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | O60513 |
| 단백질 길이 | Asp95-Ala344 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | B4GALT4, Beta-1,4-GalTase 4, Beta-1,4-galactosyltransferase 4, Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase, Beta4Gal-T4, EC:2.4.1.-, EC:2.4.1.275, EC:2.4.1.90, Lactotriaosylceramide beta-1,4-galactosyltransferase, N-acetyllactosamine synthase, Nal synthase, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4, b4Gal-T4 |
| 배경 | Beta-1,4-galactosyltransferase 4 is a ~40 kDa protein. Galactose (Gal) transferase involved in the synthesis of terminal N-acetyllactosamine (LacNac) unit present on glycan chains of glycoproteins and glycosphingolipids. Catalyzes the transfer of Gal residue via a beta1->4 linkage from UDP-Gal to the non-reducing terminal N-acetyl glucosamine 6-O-sulfate (6-O-sulfoGlcNAc) in the linearly growing chain of both N- and O-linked keratan sulfate proteoglycans. Cooperates with B3GNT7 N-acetyl glucosamine transferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer. Transfers Gal residue via a beta1->4 linkage to terminal 6-O-sulfoGlcNAc within the LacNac unit of core 2 O-glycans forming 6-sulfo-sialyl-Lewis X (sLex). May contribute to the generation of sLex epitope on mucin-type glycoproteins that serve as ligands for SELL/L-selectin, a major regulator of leukocyte migration. 1. Seko, A. et al. (2003) The Journal of biological chemistry 278, 9150-8. PMID: 12511560 2. Kitayama, K. et al. (2007) The Journal of biological chemistry 282, 30085-96. PMID: 17690104 3. Shauchuk, A. et al. (2020) Glycoconjugate journal 37, 577-588. PMID: 32827291 4. Schwientek, T. et al. (1998) The Journal of biological chemistry 273, 29331-40. PMID: 9792633 |
| 참고사항 | For research use only |
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