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| 카탈로그 번호 | HC758012 |
|---|---|
| 설명 |
Recombinant Human BAG6 Protein, N-His (HC758012) expressed in E. coli, spanning Ser697-Arg941. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P46379 |
| 단백질 길이 | Ser697-Arg941 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 29.19 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | BAG family molecular chaperone regulator 6, BAG-6, BAG6, BAT3, BCL2-associated athanogene 6, G3, HLA-B-associated transcript 3, Large proline-rich protein BAG6, Protein G3, Protein Scythe |
| 배경 | Large proline-rich protein BAG6 is a ~119 kDa protein. ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome. 1. Wang, Q. et al. (2011) Molecular cell 42, 758-70. PMID: 21636303 2. Leznicki, P. et al. (2010) Journal of cell science 123, 2170-8. PMID: 20516149 3. Hessa, T. et al. (2011) Nature 475, 394-7. PMID: 21743475 4. Shao, S. et al. (2017) Science (New York, N.Y.) 355, 298-302. PMID: 28104892 5. Mariappan, M. et al. (2010) Nature 466, 1120-4. PMID: 20676083 6. Mock, JY. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 106-11. PMID: 25535373 7. Rodrigo-Brenni, MC. et al. (2014) Molecular cell 55, 227-37. PMID: 24981174 8. Krysztofinska, EM. et al. (2016) Scientific reports 6, 26433. PMID: 27193484 9. Leznicki, P. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 19214-9. PMID: 23129660 10. Wunderley, L. et al. (2014) Journal of cell science 127, 4728-39. PMID: 25179605 |
| 참고사항 | For research use only |
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