Human BRAT1 Recombinant Protein (N-His) (HD348012)

Name: Human BRAT1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD348012
Price: 211 USD
Availability: InStock

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50ug
100ug
1mg

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개요

카탈로그 번호	HD348012
설명	Recombinant Human BRAT1 Protein, N-His (HD348012) expressed in E. coli, spanning Met1-Gly291. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
발현 시스템	E. coli
등록번호	Q6PJG6
단백질 길이	Met1-Gly291
응용 분야	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
종	Homo sapiens (Human)
성질	Recombinant
내독소 수준	Please contact with the lab for this information.
순도	>90% as determined by SDS-PAGE.
예측 분자량	33.38 kDa
형태	Lyophilized
저장 완충액	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
재구성	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
배송	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	BAAT1, BRAT1, BRCA1-associated ATM activator 1, BRCA1-associated protein required for ATM activation protein 1, C7orf27, Integrator complex assembly factor BRAT1
배경	Integrator complex assembly factor BRAT1 is a ~88 kDa protein. Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex. Associates with INTS9 and INTS11 in the cytoplasm and blocks the active site of INTS11 to inhibit the endonuclease activity of INTS11 before formation of the full integrator complex. Following dissociation of WDR73 of the complex, BRAT1 facilitates the nuclear import of the INTS9-INTS11 heterodimer. In the nucleus, INTS4 is integrated to the INTS9-INTS11 heterodimer and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6). BRAT1 is also involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. 1. Sabath, K. et al. (2024) Molecular cell 84, 2882-2899.e10. PMID: 39032489 2. Lin, MH. et al. (2024) Molecular cell 84, 2900-2917.e10. PMID: 39032490 3. Aglipay, JA. et al. (2006) The Journal of biological chemistry 281, 9710-8. PMID: 16452482 4. So, EY. et al. (2011) Experimental and therapeutic medicine 2, 443-447. PMID: 22977523 5. So, EY. et al. (2014) BMC cancer 14, 548. PMID: 25070371 6. So, EY. et al. (2013) Journal of cancer biology & research 1. PMID: 25657994
참고사항	For research use only

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Human BRAT1 Recombinant Protein (N-His).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Human BRAT1 Recombinant Protein (N-His) (HD348012)

개요

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