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| 카탈로그 번호 | HD735012 |
|---|---|
| 설명 |
Recombinant Human BTRC Protein, N-His (HD735012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q9Y297 |
| 단백질 길이 | His291-Asp581 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | BTRC, BTRCP, E3RSIkappaB, Epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, F-box/WD repeat-containing protein 1A, FBW1A, FBXW1A, pIkappaBalpha-E3 receptor subunit |
| 배경 | F-box/WD repeat-containing protein 1A is a ~68 kDa protein. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. 1. Suzuki, H. et al. (1999) Biochemical and biophysical research communications 256, 127-32. PMID: 10066435 2. Shirane, M. et al. (1999) The Journal of biological chemistry 274, 28169-74. PMID: 10497169 3. Suzuki, H. et al. (2000) The Journal of biological chemistry 275, 2877-84. PMID: 10644755 4. Orian, A. et al. (2000) The EMBO journal 19, 2580-91. PMID: 10835356 5. Heissmeyer, V. et al. (2001) Molecular and cellular biology 21, 1024-35. PMID: 11158290 6. Lassot, I. et al. (2001) Molecular and cellular biology 21, 2192-202. PMID: 11238952 7. Fukuchi, M. et al. (2001) Molecular biology of the cell 12, 1431-43. PMID: 11359933 8. Fong, A. et al. (2002) The Journal of biological chemistry 277, 22111-4. PMID: 11994270 9. Margottin-Goguet, F. et al. (2003) Developmental cell 4, 813-26. PMID: 12791267 10. Mantovani, F. et al. (2003) The Journal of biological chemistry 278, 42477-86. PMID: 12902344 |
| 참고사항 | For research use only |
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