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| 카탈로그 번호 | HC772012 |
|---|---|
| 설명 |
Recombinant Human CALCOCO2 Protein, N-His (HC772012) expressed in E. coli, spanning Ser21-Ser120. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q13137 |
| 단백질 길이 | Ser21-Ser120 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 14.28 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | Antigen nuclear dot 52 kDa protein, CALCOCO2, Calcium-binding and coiled-coil domain-containing protein 2, NDP52, Nuclear domain 10 protein 52, Nuclear domain 10 protein NDP52, Nuclear dot protein 52 |
| 배경 | Calcium-binding and coiled-coil domain-containing protein 2 is a ~52 kDa protein. Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy. Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation. Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C. May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion. 1. Thurston, TL. et al. (2012) Nature 482, 414-8. PMID: 22246324 2. von Muhlinen, N. et al. (2012) Molecular cell 48, 329-42. PMID: 23022382 3. Verlhac, P. et al. (2015) Cell host & microbe 17, 515-25. PMID: 25771791 4. Morriswood, B. et al. (2007) Journal of cell science 120, 2574-85. PMID: 17635994 |
| 참고사항 | For research use only |
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