Human CBL Recombinant Protein (N-His-KSI) (HB638022)

Name: Human CBL Recombinant Protein (N-His-KSI)
Brand: abinScience
SKU: HB638022
Price: 211 USD
Availability: InStock

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50ug
100ug
1mg

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개요
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개요

카탈로그 번호	HB638022
설명	Recombinant Human CBL Protein, N-His-KSI (HB638022) expressed in E. coli, spanning Asp52-Pro433. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
발현 시스템	E. coli
등록번호	P22681
단백질 길이	Asp52-Pro433
응용 분야	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
종	Homo sapiens (Human)
성질	Recombinant
내독소 수준	Please contact with the lab for this information.
순도	>90% as determined by SDS-PAGE.
예측 분자량	59.92 kDa
형태	Lyophilized
저장 완충액	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
재구성	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
배송	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	CBL, CBL2, Casitas B-lineage lymphoma proto-oncogene, E3 ubiquitin-protein ligase CBL, EC:2.3.2.27, Proto-oncogene c-Cbl, RING finger protein 55, RING-type E3 ubiquitin transferase CBL, RNF55, Signal transduction protein CBL
배경	E3 ubiquitin-protein ligase CBL is a ~99 kDa protein. E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors. Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Ubiquitinates EGFR and SPRY2. 1. Joazeiro, CA. et al. (1999) Science (New York, N.Y.) 286, 309-12. PMID: 10514377 2. Howlett, CJ. et al. (2002) Oncogene 21, 1707-16. PMID: 11896602 3. Kim, M. et al. (2004) Oncogene 23, 1645-55. PMID: 14661060 4. Miyazaki, T. et al. (2004) The Journal of biological chemistry 279, 17660-6. PMID: 14739300 5. Kaabeche, K. et al. (2004) The Journal of biological chemistry 279, 36259-67. PMID: 15190072 6. Bonaventure, J. et al. (2007) The FEBS journal 274, 3078-93. PMID: 17509076 7. Dufour, C. et al. (2008) Bone 42, 1032-9. PMID: 18374639 8. Wehrle, C. et al. (2009) The Biochemical journal 423, 375-80. PMID: 19689429 9. Sévère, N. et al. (2011) The Journal of biological chemistry 286, 24443-50. PMID: 21596750 10. Deschamps, T. et al. (2017) Journal of virology 91. PMID: 28381567
참고사항	For research use only

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Human CBL Recombinant Protein (N-His-KSI).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Human CBL Recombinant Protein (N-His-KSI) (HB638022)

개요

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