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| 카탈로그 번호 | HY583021 |
|---|---|
| 설명 |
Recombinant Human CD126/IL6R/IL-6RA Protein, C-Fc (HY583021) expressed in Mammalian Cells, spanning Met1-Pro365. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | Mammalian cells |
| 등록번호 | XP_038399153.1 |
| 단백질 길이 | Met1-Pro365 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 타겟 | CD126, IL-6 receptor subunit alpha, IL-6R 1, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL6R, Interleukin-6 receptor subunit alpha, Membrane glycoprotein 80, Soluble interleukin-6 receptor subunit alpha, gp80, sIL6R |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 66.62 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | CD126, IL-6 receptor subunit alpha, IL-6R 1, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL6R, Interleukin-6 receptor subunit alpha, Membrane glycoprotein 80, Soluble interleukin-6 receptor subunit alpha, gp80, sIL6R |
| 배경 | Interleukin-6 receptor subunit alpha is a ~51 kDa protein. Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. 1. Larsen, JV. et al. (2017) Molecular and cellular biology 37. PMID: 28265003 2. Kang, S. et al. (2019) Immunity 50, 1007-1023. PMID: 30995492 3. Spencer, S. et al. (2019) The Journal of experimental medicine 216, 1986-1998. PMID: 31235509 |
| 참고사항 | For research use only |
Immobilized HY583021 Human CD126/IL6R/IL-6RA Recombinant Protein (C-Fc) at 2 μg/mL(100 μL/well) can bind HY328011 Human IL6 Recombinant Protein (C-His-Avi), the EC 50 is 63.7 ng/mL.
Immobilized HY583021 Human CD126/IL6R/IL-6RA Recombinant Protein (C-Fc) at 2 μg/mL(100 μL/well) can bind HY328021 Human IL6 Recombinant Protein (C-His), the EC 50 is 115 ng/mL.
Immobilized HY328011 Human IL6 Recombinant Protein (C-His-Avi) at 2 μg/mL(100 μL/well) can bind HY583021 Human CD126/IL6R/IL-6RA Recombinant Protein (C-Fc), the EC 50 is 222 ng/mL.
Immobilized HY328021 Human IL6 Recombinant Protein (C-His) at 2 μg/mL(100 μL/well) can bind HY583021 Human CD126/IL6R/IL-6RA Recombinant Protein (C-Fc), the EC 50 is 162 ng/mL.
Immobilized HY328041 Human IL6 Recombinant Protein (N-HSAD3 & C-His) at 2 μg/mL(100 μL/well) can bind HY583021 Human CD126/IL6R/IL-6RA Recombinant Protein (C-Fc), the EC 50 is 133 ng/mL.
Immobilized HY328051 Human IL6 Recombinant Protein (C-Strep) at 2 μg/mL(100 μL/well) can bind HY583021 Human CD126/IL6R/IL-6RA Recombinant Protein (C-Fc), the EC 50 is 267 ng/mL.
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