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| 카탈로그 번호 | HD887012 |
|---|---|
| 설명 |
Recombinant Human CERS6 Protein, N-His (HD887012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q6ZMG9 |
| 단백질 길이 | Glu56-Asp177 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | CERS6, CerS6, Ceramide synthase 6, EC:2.3.1.-, EC:2.3.1.291, LAG1 longevity assurance homolog 6, LASS6, Sphingoid base N-palmitoyltransferase CERS6 |
| 배경 | Ceramide synthase 6 is a ~44 kDa protein. Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA). Can use other acyl donors, but with less efficiency. N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Ceramides generated by CERS6 play a role in inflammatory response. Acts as a regulator of metabolism and hepatic lipid accumulation. 1. Mesika, A. et al. (2007) The Journal of biological chemistry 282, 27366-27373. PMID: 17609214 2. Lahiri, S. et al. (2007) FEBS letters 581, 5289-94. PMID: 17977534 3. Russo, SB. et al. (2013) The Journal of biological chemistry 288, 13397-409. PMID: 23530041 4. Sassa, T. et al. (2016) The Journal of biological chemistry 291, 7477-87. PMID: 26887952 5. Jojima, K. et al. (2020) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 34, 3318-3335. PMID: 31916624 6. Pascoa, TC. et al. (2025) Nature structural & molecular biology 32, 431-440. PMID: 39528795 |
| 참고사항 | For research use only |
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