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| 카탈로그 번호 | HB019022 |
|---|---|
| 설명 |
Recombinant Human CHRNA3 Protein, N-His (HB019022) expressed in E. coli, spanning Ser32-Leu240. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P32297 |
| 단백질 길이 | Ser32-Leu240 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 26.91 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | CHRNA3, NACHRA3, Neuronal acetylcholine receptor subunit alpha-3 |
| 배경 | Neuronal acetylcholine receptor subunit alpha-3 is a ~57 kDa protein. Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA3 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, with CHRNA5, and CHRNB3 as accesory subunits. CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor. 1. Gharpure, A. et al. (2019) Neuron 104, 501-511.e6. PMID: 31488329 2. Mann, N. et al. (2019) American journal of human genetics 105, 1286-1293. PMID: 31708116 3. Kuryatov, A. et al. (2011) Molecular pharmacology 79, 119-25. PMID: 20881005 4. Wang, F. et al. (1996) The Journal of biological chemistry 271, 17656-65. PMID: 8663494 |
| 참고사항 | For research use only |
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