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| 카탈로그 번호 | HC966012 |
|---|---|
| 설명 |
Recombinant Human CLPX Protein, N-His (HC966012) expressed in E. coli, spanning Ser287-Ala605. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | O76031 |
| 단백질 길이 | Ser287-Ala605 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 37.19 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial, ATP-dependent clpX-like chaperone, mitochondrial, CLPX, Caseinolytic mitochondrial matrix peptidase chaperone subunit X, EC:3.6.4.10 |
| 배경 | ATP-dependent clpX-like chaperone, mitochondrial is a ~69 kDa protein. ATP-dependent chaperone that functions as an unfoldase. As part of the ClpXP protease complex, it recognizes specific protein substrates, unfolds them using energy derived from ATP hydrolysis, and then translocates them to the proteolytic subunit (CLPP) of the ClpXP complex for degradation. Thanks to its chaperone activity, it also functions in the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. This chaperone is also involved in the control of mtDNA nucleoid distribution, by regulating mitochondrial transcription factor A (TFAM) activity. 1. Kang, SG. et al. (2002) The Journal of biological chemistry 277, 21095-102. PMID: 11923310 2. Lowth, BR. et al. (2012) Journal of structural biology 179, 193-201. PMID: 22710082 3. Yien, YY. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E8045-E8052. PMID: 28874591 4. Kasashima, K. et al. (2012) Experimental cell research 318, 2335-43. PMID: 22841477 |
| 참고사항 | For research use only |
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