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| 카탈로그 번호 | HD953012 |
|---|---|
| 설명 |
Recombinant Human CPT1C Protein, N-His (HD953012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q8TCG5 |
| 단백질 길이 | Ser178-Gln790 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | CATL1, CPT I-C, CPT1C, CPTI-B, Carnitine O-palmitoyltransferase 1, brain isoform, Carnitine palmitoyltransferase 1C, Carnitine palmitoyltransferase I, EC:3.1.2.22, Palmitoyl thioesterase CPT1C |
| 배경 | Palmitoyl thioesterase CPT1C is a ~90 kDa protein. Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1. Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner. Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control. Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels. 1. Gratacòs-Batlle, E. et al. (2018) Frontiers in molecular neuroscience 11, 275. PMID: 30135643 2. Wolfgang, MJ. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 7282-7. PMID: 16651524 3. Rinaldi, C. et al. (2015) JAMA neurology 72, 561-70. PMID: 25751282 |
| 참고사항 | For research use only |
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