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| 카탈로그 번호 | HD264012 |
|---|---|
| 설명 |
Recombinant Human CTC1 Protein, N-His (HD264012) expressed in E. coli, spanning Asp893-Cys1217. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q2NKJ3 |
| 단백질 길이 | Asp893-Cys1217 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 38.14 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | C17orf68, CST complex subunit CTC1, CTC1, Conserved telomere maintenance component 1, HBV DNAPTP1-transactivated protein B |
| 배경 | CST complex subunit CTC1 is a ~134 kDa protein. Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. 1. Miyake, Y. et al. (2009) Molecular cell 36, 193-206. PMID: 19854130 2. Chen, LY. et al. (2012) Nature 488, 540-4. PMID: 22763445 3. Wang, F. et al. (2014) Cell cycle (Georgetown, Tex.) 13, 3488-98. PMID: 25483097 4. Surovtseva, YV. et al. (2009) Molecular cell 36, 207-18. PMID: 19854131 5. Stewart, JA. et al. (2012) The EMBO journal 31, 3537-49. PMID: 22863775 |
| 참고사항 | For research use only |
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