Human CXCL10/IP-10 Recombinant Protein (N-GST & C-His) (HY524032)

Name: Human CXCL10/IP-10 Recombinant Protein (N-GST & C-His)
Brand: abinScience
SKU: HY524032
Price: 211 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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50ug
100ug
1mg

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HY524032
설명	Recombinant Human CXCL10/IP-10 Protein, N-GST & C-His (HY524032) expressed in E. coli, spanning Val22-Pro98. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
발현 시스템	E. coli
등록번호	P02778
단백질 길이	Val22-Pro98
응용 분야	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
종	Homo sapiens (Human)
성질	Recombinant
내독소 수준	Please contact with the lab for this information.
순도	>90% as determined by SDS-PAGE.
예측 분자량	36.83 kDa
형태	Lyophilized
저장 완충액	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
재구성	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
배송	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	10 kDa interferon gamma-induced protein, C-X-C motif chemokine 10, CXCL10, CXCL10(1-73), Gamma-IP10, INP10, IP-10, SCYB10, Small-inducible cytokine B10
배경	C-X-C motif chemokine 10 is a ~10 kDa protein. Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. 1. Romagnani, P. et al. (2001) Blood 97, 601-7. PMID: 11157474 2. Sidahmed, AM. et al. (2012) Cytokine 59, 433-41. PMID: 22652417 3. Angiolillo, AL. et al. (1995) The Journal of experimental medicine 182, 155-62. PMID: 7540647 4. Smit, MJ. et al. (2003) Blood 102, 1959-65. PMID: 12750173 5. Gao, JM. et al. (2009) Acta pharmacologica Sinica 30, 193-201. PMID: 19151743 6. Cheeran, MC. et al. (2003) Journal of virology 77, 4502-15. PMID: 12663757
참고사항	For research use only